diff --git a/crates/engine/src/cmd/opacitymask.rs b/crates/engine/src/cmd/opacitymask.rs
index 1fb173daa..37dadf5aa 100644
--- a/crates/engine/src/cmd/opacitymask.rs
+++ b/crates/engine/src/cmd/opacitymask.rs
@@ -167,13 +167,15 @@ fn masked_targets(s: &Session, p: &Value) -> Result<Vec<NodeId>> {
 /// ([`super::maskedit::outside_isolation_mode`]). The selection is one object when it has one
 /// subject root, which `make` masks without `ids`, and at most one outermost object, which it
 /// masks with `ids` (a call's `ids` stand in for the selection here). `make` itself refuses any
-/// single target in isolation mode, a layer included.
+/// single target in isolation mode, a layer included, so a selection with a target counts as one
+/// object.
 fn can_make(s: &Session) -> std::result::Result<(), String> {
     has_doc(s)?;
     let Some(st) = s.active() else { return Ok(()) };
     let roots = super::appearance::subject_roots(s).map_or(0, |r| r.len());
     let outermost = super::edit::outermost(&st.doc, st.selection.in_paint_order(&st.doc)).len();
-    if roots == 1 && outermost <= 1 { super::maskedit::outside_isolation_mode(s) } else { Ok(()) }
+    let targeted = st.selection.target.is_some();
+    if roots == 1 && (outermost <= 1 || targeted) { super::maskedit::outside_isolation_mode(s) } else { Ok(()) }
 }
 
 fn make(s: &mut Session, p: &Value) -> Result<Value> {
diff --git a/crates/engine/src/tests/opacitymask.rs b/crates/engine/src/tests/opacitymask.rs
index d76677bad..74d6770e3 100644
--- a/crates/engine/src/tests/opacitymask.rs
+++ b/crates/engine/src/tests/opacitymask.rs
@@ -308,6 +308,24 @@ fn opacity_mask_editing_is_not_entered_in_isolation_mode() {
     assert_eq!(doc(&s).mask_edit.map(|e| e.object), Some(obj));
 }
 
+/// In isolation mode, Make Opacity Mask is off for a targeted sublayer that holds two objects:
+/// the sublayer is its one target, which would get an empty mask and enter mask editing.
+#[test]
+fn make_opacity_mask_is_off_for_a_targeted_sublayer_in_isolation_mode() {
+    let mut s = session();
+    let layer = doc(&s).layers[0].id;
+    let sub = NodeId(s.execute("layer.newSublayer", &json!({"parent": layer.0})).unwrap()["id"].as_u64().unwrap());
+    s.execute("layer.setCurrent", &json!({"id": sub.0})).unwrap();
+    let (a, b) = (rect(&mut s, 0.0, 20.0), rect(&mut s, 40.0, 20.0));
+    s.execute("object.isolate", &json!({"id": layer.0})).unwrap();
+    s.execute("layer.target", &json!({"id": sub.0})).unwrap();
+    assert_eq!(s.doc().unwrap().selection.target, Some(sub));
+    off(&mut s, "transparency.makeOpacityMask", json!({}), "exit isolation mode first");
+    // Two objects given in `ids` still mask one with the other.
+    let r = s.execute("transparency.makeOpacityMask", &json!({"ids": [a.0, b.0]})).unwrap();
+    assert_eq!(r["editing"], json!(false));
+}
+
 #[test]
 fn mask_and_transparency_commands_take_ids_without_a_selection() {
     let mut s = session();